Detecting Selection in Noncoding Regions of Nucleotide Sequences
نویسندگان
چکیده
منابع مشابه
Detecting selection in noncoding regions of nucleotide sequences.
We present a maximum-likelihood method for examining the selection pressure and detecting positive selection in noncoding regions using multiple aligned DNA sequences. The rate of substitution in noncoding regions relative to the rate of synonymous substitution in coding regions is modeled by a parameter zeta. When a site in a noncoding region is evolving neutrally zeta = 1, while zeta > 1 indi...
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متن کاملDetecting selection on nucleotide polymorphisms
At this point, we’ve refined the neutral theory quite a bit. Our understanding of how molecules evolve now recognizes that some substitutions are more likely than others, but we’re still proceeding under the assumption that most nucleotide substitutions are neutral or detrimental. So far we’ve argued that variation like what Hubby and Lewontin [3, 7] found is not likely to be maintained by natu...
متن کاملDetecting selection on nucleotide polymorphisms
At this point, we’ve refined the neutral theory quite a bit. Our understanding of how molecules evolve now recognizes that some substitutions are more likely than others, but we’re still proceeding under the assumption that most nucleotide substitutions are neutral or detrimental. So far we’ve argued that variation like what Hubby and Lewontin [2, 6] found is not likely to be maintained by natu...
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ژورنال
عنوان ژورنال: Genetics
سال: 2004
ISSN: 1943-2631
DOI: 10.1534/genetics.102.010959